The Saturday evening kick-off comes after the England midfielder admitted to aggravating an ankle injury in the win over Newcastle last time out, although he has since been pictured in training.
“Unfortunately today I’ve kind of damage it again but now I need to rest up,” he said. “We’ve got two days off now so hopefully I’ll maintain the chance to rest it.”
John Stones has also been involved in City’s workouts as he looks to return from a hamstring injury suffered in January, which cleared up sufficiently for him to design the bench against Newcastle.
Pep Guardiola is unlikely to rotate his side too much despite the upcoming visit of RB Leipzig in the Champions League, although the latest off-field issues for Kyle Walker may impact his selection.
As for Crystal Palace, Cheick Doucoure is suspended following his dismissal against Aston Villa last weekend.
Will Hughes, Luka Milivojevic and James McArthur will compete to add steel to the Eagles’ midfield with Wilfried Zaha likely to continue up front. Sam Johnstone and Nathan Ferguson are long-term injury absentees.
Predicted Crystal Palace XI: Guaita; Clyne, Andersen, Guehi, Mitchell; Hughes, Lokonga; Olise, Eze, Ayew; Zaha.
Predicted Man City XI: Ederson; Walker, Stones, Laporte, Silva; De Bruyne, Rodri, Gundogan; Mahrez, Haaland, Grealish.