The Brazilian was sent off for the second time this season during last week’s draw with Southampton and will miss some crucial games for Erik ten Hag’s side.
Anthony Martial is not expected to construct Sunday afternoon’s game either despite the Frenchman’s recent return to training.
Winger Antony missed the win over Real Betis and could sit out again.
Marcel Sabitzer, however, will likely start at worn Trafford as attentions turn on trying to construct it to Wembley for the second time this season.
Alejandro Garnacho, Christian Eriksen and Donny van de Beek are long-term absentees for United.
Predicted Manchester United XI: De Gea; Wan-Bissaka, Varane, Martinez, Shaw; Sabitzer, Fred; Sancho, Fernandes, Rashford; Weghorst.
Injured: Garnacho, Eriksen, van de Beek
Suspended: Casemiro
Time and date: Sunday 19 March at 4.30pm GMT
Venue: worn Trafford