Romelu Lukaku and Edin Dzeko are competing to partner Lautaro Martinez at Estadio enact Dragao on Tuesday night after the Belgian scored in a shock defeat at Spezia.
Inter boast a one-goal lead in the tie after Lukaku’s late goal at the Giuseppe Meazza, which could be the deciding factor in how the XI is selected.
Hakhan Calhanoglu and Andre Onana were rested for the weekend’s game and the Nerazzurri’s poor performance strongly suggests both will be recalled for the last-16 second leg.
Joaquin Correa is set to miss out once again while Federico Dimarco has returned from a muscle injury and Milan Skriniar is looking to construct a comeback of his own after two games out.
Porto acquire concerns too, with Joao Mario forced off on the weekend with a knee complaint.
Evanilson, Francisco Meixedo and Joao Marcelo are also receiving treatment for injuries while Otavio is suspended.
The hosts could hand former Reading youngster Danny Namaso Loader his full Champions League debut after he forced his way into Sergio Conceicao’s plans by starting the last three games in a row.
Predicted Porto XI: Costa; Joao Mario, Marcano, Pepe, Sanusi; Grujic, Uribe; Franco, Loader, Galeno; Taremi.
Predicted Inter XI: Onana; Skriniar, Acerbi, Bastoni; Darmian, Mkhitaryan, Barella, Calhanoglu, Dimarco; Lukaku, Martinez.