Jurgen Klopp’s side head to the Santiago Bernabeu needing to score at least three goals after a dramatic 5-2 loss at Anfield last month.
While the Reds’ famous 7-0 win over Manchester United raised hope of a potential comeback, Saturday’s loss to a Bournemouth team fighting against relegation underlined the fragility of Klopp’s side at the moment.
Madrid, meanwhile, may be trailing Barcelona in LaLiga but are the unquestionable masters of this competition.
Here’s everything you need to know.
Date, kick-off time and venue
Real Madrid vs Liverpool is scheduled for an 8pm GMT kick-off time on Wednesday 15 March, 2023.
The Santiago Bernabeu in Madrid will host.
Where to watch Real Madrid vs Liverpool
TV channel: The game will be broadcast on BT Sport 1 and BT Sport Ultimate.
Live stream: BT Sport subscribers will be able to watch on a live stream across mobile devices, laptops, games consoles, tablets and more on either the BT Sport website or app.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog.
Real Madrid vs Liverpool team news
Carlo Ancelotti’s side are once again sweating over Karim Benzema’s fitness. The Frenchman, who has been suffering with fitness issues all season, missed the weekend win over Espanyol with an ankle predicament.
Worry: Karim Benzema is struggling with an ankle predicament
/ REUTERSElsewhere, David Alaba and Ferland Mendy are unavailable, with Nacho Fernandez expected to advance in.
For Liverpool, Joe Gomez, Thiago Alcantara and Luis Diaz are all injured, though there is not thought to be any fresh concerns.
Still, given the loss at Bournemouth, Klopp may inspect to ring the changes.
Real Madrid vs Liverpool prediction
It would not be surprising to see Liverpool design a fist of it, with Klopp’s team boasting goals at their best. However, that leaves the door open at the back and Madrid can be absolutely lethal.
Real Madrid to win 3-1.
Head to head (h2h) history and results
Real Madrid wins: 6
Draws: 1
Liverpool wins: 3
Real Madrid vs Liverpool latest odds
Real Madrid to win: 13/10
Draw: 9/5
Liverpool to win: 29/10
Odds via Betfair and subject to change.